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Abstract Detail

Mycological Section

Raudabaugh, Daniel [1], Miller, Andrew N. [2], Taylor, Steven J. [2], Heske, Edward J. [2], Merritt, Joseph F. [2], Yannarell, Anthony C. [3], Mateus-Pinilla, Nohra E. [2].

Trans, trans-farnesol from Candida albicans can kill or inhibit Pseudogymnoascus destructans .

Bat white-nose syndrome, caused by the psycrophilic fungus Pseudogymnoascus destructans, has dramatically reduced the populations of many hibernating North American bat species. The search for effective biological control agents targeting P. destructans is of great importance. We report that the sesquiterpene trans, trans-farnesol, which is produced by the yeast/fungus Candida albicans, prevented in vitro conidial germination for at least 14 days and caused cell death in hyphal fragments of 5 P. destructans isolates in filtered potato dextrose broth at 10 °C. Depending on the inoculation concentrations, both spore inhibition and hyphal cell death occurred upon exposure to concentrations as low as 15-20 µM trans, trans-farnesol. In contrast, 3 different Pseudogymnoascus isolates were less sensitive to the exposure of trans, trans-farnesol. Isolate 05NY09 demonstrated dramatic reduction of hyphal growth and increased hyphal branching when exposed to 100 µM trans, trans-farnesol, while another isolate (LJ177) demonstrated no reduction in growth at 100 µM trans, trans-farnesol, but displayed out growths reminiscent of secondary conidia at 300 µM. The growth of a yeast-like isolate (LJ130) appeared unaffected by 300 µM trans, trans-farnesol. Our results suggest that some Candida isolates may have the potential to inhibit the growth of P. destructans and that the sesquiterpene trans, trans-farnesol has the potential to be utilized as an environmental control agent.

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1 - University of Illinois at Urbana-Champaign, Department of Plant Biology, 1816 South Oak Street, MC-652, Champaign, IL, 61820, USA
2 - University of Illinois Urbana-Champaign, Illinois Natural History Survey, Champaign, IL, 61820, USA
3 - University of Illinois Urbana-Champaign, Department of Natural Resources and Environmental Sciences, S-522 Turner Hall , 1102 S. Goodwin, Urbana , IL, 61801, USA

biological control
White nose syndrome.

Presentation Type: Poster:Posters for Sections
Session: P
Location: Hall D/The Shaw Conference Centre
Date: Monday, July 27th, 2015
Time: 5:30 PM
Number: PMY039
Abstract ID:743
Candidate for Awards:None

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